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This course will provide in-depth coverage of the preclinical drug discovery and design process, with a special emphasis on the key role of biochemistry at each stage. Biochemical knowledge and skills are required from the early identification of a therapeutic target and hit compounds, through hit-to-lead optimization, to establishing preclinical “absorption, distribution, metabolism, excretion and toxicity” profiles (ADMET) for lead compounds. Discussion of emerging areas in therapeutic design and case studies, both from literature and on-going research programs, will be included to give context to the lecture series. Due to the dynamic nature of many of the aspects of drug discovery, this course will be regularly updated to reflect new trends and technologies.

College/Department: COM School of Biomedical Sciences Professional Studies
Repeat Status: Not repeatable for credit